Ep. 120: Vitamin A Toxicity: Retinoic Acid Toxicity, Accutane, and Whether Hypervitaminosis A Exists

In this episode we discuss: The research behind vitamin A toxicity and whether vitamin A is really a poison Whether you need to be concerned about the use of Accutane Whether retinoic acid is toxic because it’s used as a chemotherapeutic agent Whether Grant Genereux’s claims about vitamin A toxicity are valid   Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide   Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-120-vitamin-a-toxicity-retinoic-acid-toxicity-accutane-and-whether-hypervitaminosis-a-exists   Timestamps: 0:00 – intro 1:15 – why we're examining Grant Genereux's take on vitamin A toxicity and the evidence behind his claims 4:50 – conceptualizing the amount of vitamin A needed for toxicity 7:07 – is hypervitaminosis A (vitamin A toxicity) real? 9:27 – cautioning against the idea of "detox" as an excuse for negative effects and vitamin A toxicity as an unfalsifiable hypothesis 12:36 – is there a conspiracy to poison the masses with vitamin A? 18:36 – how likely is it that you have vitamin A toxicity? 22:30 – problems with the first in vivo study that Grant uses to support vitamin A toxicity 35:14 – vitamin A toxicity in the studies Grant cited require massive doses of vitamin A that would be impossible to obtain from diet 42:44 – Grant’s cited research actually supports the safety of vitamin A 50:52 – more of Grant’s cited research supporting vitamin A safety 58:25 – further research supporting that extremely high doses are required to cause vitamin A toxicity 1:07:57 – whether vitamin A toxicity is driving autoimmunity 1:09:54 – whether retinoic acid is toxic based on concerns regarding the use of Accutane  1:15:40 – how conflating Accutane with retinoic acid is misleading  1:22:12 – whether retinoic acid is toxic because Accutane is used as a chemotherapeutic agent  1:29:37 – evaluating Grant’s claim that retinol automatically becomes “toxic” retinoic acid  1:35:05 – our concluding thoughts on Grant’s arguments regarding vitamin A toxicity