Ep. 129: The Forgotten Source of Oxalates: Your Body’s OWN Production

In this episode we discuss:   How much oxalate your body produces and how it compares to the amount you consume in your diet Whether you need to be concerned about vitamin C, hydroxyproline, and glycine converting to oxalates How you can reduce the amount of oxalates your body produces Which nutrients decrease oxalate production How metabolic dysfunction affects oxalate production   Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/   The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/   Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-129-the-forgotten-source-of-oxalates-your-bodys-own-production/   Timestamps: 0:00 – intro  1:12 – overview of endogenous vs. exogenous oxalates  5:46 – how much oxalate comes from endogenous production vs. diet  9:14 – when endogenous oxalate production matters more than dietary oxalate  15:03 – rare genetic disorders that cause excessive oxalate production: primary hyperoxaluria  22:36 – the pathways in the liver that lead to oxalate production  32:41 – other biochemical pathways involved in endogenous oxalate production  41:19 – deranged metabolic function as a primary driver of glyoxal production and lipid peroxidation  45:14 – the extent to which glycine and vitamin C contribute to endogenous oxalate formation  48:00 – how much does hydroxyproline contribute to oxalate production?  52:06 – the primary precursor to oxalate that’s often ignored (glyoxal)  55:08 – how oxidative stress drives oxalate production and how antioxidants help  1:01:20 – what causes the high oxalate levels seen in type 2 diabetes, obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD)?  1:11:16 – the protective effects of glycine in states of excess oxalate production  1:15:54 – elevated stress hormones and gluconeogenesis increase oxalate production  1:22:43 – nutrient deficiencies that contribute to oxalate issues (vitamin B1, vitamin B6, and zinc)